Compuestos derivados de piperazina, composiciones farmaceuticas y metodos de tratamiento con las mismas

Compuestos derivados de piperazina, métodos de tratamiento y composiciones farmacéuticas. Estos compuestos son potencialmente útiles para el tratamiento o prevención de enfermedades autoinmunes, afecciones inflamatorias agudas y crónicas, afeccionesalérgicas asociadas a la inflamación. Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, en la que: a es 1, 2, 3, 4 o 5; b es 0, 1, 2, 3 o 4; c es 0 o 1; d es 1, 2, 3, 4, o 5; e es 0 o 1; j es 1, 2, 3 o 4; X es C(O), C(S) oCH2; Y es CH2, o si e es 0, Y es CHR8 siendo R8 hidrogeno, arilo C6-10 o NR9R10; Z es oxígeno, NR9 o CR11R12; cada R1 se selecciona independientemente entre hidrógeno, hidroxi, hidroxisulfonilo, halo, alquilo C1-6, mercapto, mercaptoalquilo C1-6,alquil C1-6 tio, alquil C1-6 sulfinilo, alquil C1-6 sulfonilo, alquil C1-6 tioalquilo C1-6, alquil C16 sulfinilalquilo C1-6, alquil C1-6 sulfonilalquilo C1-6, alcoxi C1-6, ariloxi C6-10, haloalquilo C1-6, trifluorometilo, formilo, formilalquiloC1-6, nitro, nitroso, ciano, aril C6-10 alcoxi C1-6, haloalcoxi C1-6, trifluorometoxi, cicloalquilo C3-7, cicloalquil C3-7 alquilo C1-6, hidroxicicloalquil C3-7 alquilo C1-6, cicloalquil C3-7 amino, cicloalquil C3-7 aminoalquilo C1-6, (cicloalquilC3-7)(alquil C1-6)amino, (cicloalquil C3-7 alquil C1-6) aminoalquilo C1-6, cianoalquilo C1-6, alquenilo C2-7, alquinilo C2-7, arilo C6-10, aril C6-10 alquilo C1-6, aril C6-10 alquenilo C2-6, hidroxi-alquilo C1-6, hidroxiaril C6-10 alquilo C1-6,hidroxialquil C1-6 tioalquilo C1-6, hidroxialquenilo C2-6, hidroxialquinilo C2-6, alcoxi C1-6 alquilo C1-6, alcoxi C1-6 aril C6-10 alquenilo C1-6, ariloxi C6-10 alquilo C1-6, aril C6-10 alcoxi C1-6 alquilo C1-6, amino, alquil C1-6 amino, (alquilC1-6)2 amino, aril C6-10 amino, aril C6-10 alquil C1-6 amino, aminoalquilo C1-6, alquil C1-6 aminoalquilo C1-6, (alquil C1-6)2 aminoalquilo, hidroxialquil C1-6 aminoalquilo C1-6, aril C6-10 aminoalquilo C1-6, arilo C6-10, alquil C1-6 aminoalquiloC1-6, alquil C1-6 carbonilamino, (alquil C1-6 carbonil)(alquil C1-6) amino, alquil C1-6 carbonilaminoalquilo C1-6, (alquil C1-6 carbonil) (alquil C1-6)aminoalquilo C1-6, alcoxi C1-6 carbonilamino, (alcoxi C1-6 carbonil) alquil C1-6 amino, alcoxiC1-6 carbonilaminoalquilo C1-6, (alcoxi C1-6 carbonil)(alquil C1-6 aminoalquilo C1-6, carboxi, alcoxi C1-6 carbonilo, aril C6-10 alcoxi C1-6 carbonilo, alquil C1-6 carbonilo, alquil C1-6 carbonilalquilo C1-6, aril C6-10 carbonilo, aril C6-10carbonilalquilo C1-6, aril C6-10 alquil C1-6 carbonilo, aril C6-10 alquil C1-6 carbonilalquilo C1-6, carboxialquilo C1-6, alcoxi C1-6 carbonilalquilo C1-6, aril C6-10 alcoxi C1-6 carbonil-alquilo C1-6, alcoxi C1-6 alquil C1-6 carboniloxi-alquiloC1-6, aminocarbonilo, alquil C1-6 aminocarbonilo, (alquil C1-6)2 aminocarbonilo, aril C6-10 aminocarbonilo, aril C6-10 alquil C1-6 aminocarbonilo, aminocarbonilalquilo C1-6, alquil C1-6 aminocarbonilalquilo C1-6, (alquil C1-6)2 aminocarbonilalquiloC1-6, aril C6-10 aminocarbonilalquilo C1-6, alquil C1-6 aminocarbonilalquilo C1-6, amidino, guanidino, ureido, alquil C1-6 ureido, (alquil C1-6)2 ureido, ureidoalquilo C1-6, alquil C1-6 ureidoalquilo C1-6, (alquil C1-6)2 ureidoalquilo C1-6,heterocicloalquilo C2-9, heteroarilo C2-9, heterocicloalquil C2-9 alquilo C1-6 y heteroaril C2-9 alquilo C1-6; cada R2 y R3 se selecciona independientemente entre oxo, halo, alquilo C1-6, cicloalquilo C3-8, cicloalquil C3-8 alquilo C1-6, cicloalquilC3-8 aminoalquilo C1-6, cicloalquil C3-8 alquil C1-6 aminoalquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo C6-10, aril C6-10 alquilo C1-6, aril C6-10 alquenilo C2-6, H-C(O)-, H-C-(O)-alquilo C1-6, hidroxialquilo C1-6,hidroxialquenilo C2-6, hidroxialquinilo C2-6, hidroxiaril C6-10 alquilo C1-6, hidroxicicloalquil C3-8 alquilo C1-6, tioalquilo C1-6, cianoalquilo C1-6, haloalquil C1-6 carbonilaminoalquilo C1-6, alcoxi C1-6 aril C6-10 alquilo C1-6, alcoxi C1-6alquilo C1-6, ariloxi C6-10 alquilo C1-6, aril C6-10 alcoxi C1-6 alquilo C1-6, alquil C1-6 tioalquilo C1-6, alquil C1-6 sulfinilalquilo C1-6, alquil C1-6 sulfonilalquilo C1-6, hidroxialquil C1-6 tioalquilo C1-6, aminoalquilo C1-6, alquil C1-6aminoalquilo C1-6, (alquil C1-6)2 aminoalquilo C1-6, aril C6-10 aminoalquilo C1-6, aril C6-10 alquil C1-6 aminoalquilo C1-6, alquil C1-6 carbonilaminoalquilo C1-6, azidoalquilo C1-6, aminocarbonilaminoalquilo C1-6, alquil C1-6aminocarbonilaminoalquilo C1-6, (alquil C1-6)2 aminocarbonilaminoalquilo C1-6, alcoxi C1-6, carbonilalquil C1-6 aminocarbonilaminoalquilo C1-6, alcoxi C1-6 carbonilaminoalquilo C1-6, hidroalquil C1-6 aminoalquilo C1-6, ariloxi C6-10 alquil C1-6,carboniloxialquilo C1-6, alcoxi C1-6 alquil C1-6 carboniloxialquilo C1-6, aril C6-10 alcoxi C1-6 alquil C1-6 carboniloxialquilo C1-6, alquil C1-6 carbonilo, alquil C1-6 carbonilalquilo C1-6, carboxi, alcoxi C1-6 carbonilo, aril C6-10 alcoxi C1-6carbonilo, aril C6-10 alquil C1-6 carbonilo, aminocarbonilo, alquil C1-6 aminocarbonilo, (alquil C1-6)2 aminocarbonilo, aril C6-10 aminocarbonilo, aril C6-10 alquil C1-6 aminocarbonilo, carboxialquilo C1-6, alcoxi C1-6 carbonilalquilo C1-6, arilC6-10 alcoxi C1-6 carbonilalquilo C1-6, aminocarbonilalquilo C1-6, alquil C1-6 aminocarbonilalquilo C1-6, (alquil C1-6)2 aminocarbonilalquilo C1-6, aril C6-10 aminocarbonilalquilo C1-6, aril C6-10 alquil C1-6 aminocarbonilalquilo C1-6, aril C6-10sulfonilo, heterocicloalquilo C2-9, heteroarilo C2-9, heterocicloalquil C2-9 alquilo C1-6, heteroaril C2-9 alquilo C1-6 o R14R15N-alquilo C1-6, siendo cada uno de R14 y R15 , independientemente, alquilo C1-6 o alquil C1-6 carbonilo; R4 es (R5)f(R6)garilo C6-10, (R5)f(R6)g cicloalquilo C3-10, (R5)f(R7)h heteroarilo C2-9 o (R5)f(R7)h heterocicloalquilo C2-9, siendo f 1, 2, 3, o 4; siendo g y h independientemente 0, 1, 2 o 3; R5 es uno a tres grupos seleccionados independientemente entreheterocicloalquil C2-9 carbonilo, heteroaril C2-9 carbonilo, heteroaril C2-9 alquil C1-6 aminocarbonilo, heterocicloalquil C2-9 alquil C1-6 aminocarbonilo, alquil C1-6 sulfonilaminoalquil C1-6 aminocarbonilo, ureidoalquil C1-6 aminocarbonilo, alquilC1-6 ureidoalquil C1-6 aminocarbonilo, (alquil C1-6)2 ureidoalquil C1-6 aminocarbonilo, haloalquil C1-6 aminocarbonilo, aminosulfonilalquil C1-6 aminocarbonilo, alquil C1-6 aminosulfonilalquil C1-6 aminocarbonilo, alquil C1-6 sulfonilaminoalquilC1-6 carbonilamino, cianoguanidinoalquil C1-6 carbonilamino, alquil C1-6 cianoguanidinoalquil C1-6 carbonilamino, (alquil C1-6)2 cianoguanidinoalquil C1-6 carbonilamino, aminocarbonilalquil C1-6 carbonilamino, heteroaril C2-9 alquil C1-6carbonilamino, heterocicloalquil C2-9 alquil C1-6 carbonilamino, aminosulfonilalquil C1-6 carbonilamino, hidroxialquil C1-6 ureido, aminoalquil C1-6 ureido, alquil C1-6 aminoalquil C1-6 ureido, (alquil C1-6)2 aminoalquil C1-6 ureido,heterocicloalquil C2-9 alquil C1-6 ureido, heteroaril C2-9 alquil C1-6 ureido, aminosulfonilalquil C1-6 ureido, aminocarbonilalquil C1-6 ureido, alquil C1-6 aminocarbonilalquil C1-6 ureido, (alquil C1-6)2 aminocarbonilalquil C1-6 ureido,acetilaminoalquil C1-6 ureido, (acetil)(alquil C1-6) aminoalquil C1-6 ureido, haloalquil C1-6 sulfonilamino, aminoalquil C1-6 sulfonilamino, alquil C1-6 aminoalquil C1-6 sulfonilamino, (alquil C1-6)2 aminoalquil C1-6 sulfonilamino, acetilaminoalquilC1-6 sulfonilamino, (acetil)(alquil C1-6)aminoalquil C1-6 sulfonilamino, ureidoalquil C1-6 sulfonilamino , alquil C1-6 ureidoalquil C1-6 sulfonilamino, (alquil C1-6)2 ureidoalquil C1-6 sulfonilamino, alquil C1-6 sulfonilaminoalquil C1-6sulfonilamino, cianoguanidinoalquil C1-6 sulfonilamino, alquil C1-6 cianoguanidinoalquil C1-6 sulfonilamino, (alquil C1-6)2 cianoguanidinoalquil C1-6 sulfonilamino, aminocarbonilalquil C1-6 sulfonilamino, alcoxi C1-6 carbonilaminoalquil C1-6sulfonilamino, aminosulfonilamino, alquil C1-6 aminosulfonilamino, (alquil C1-6)2 aminosulfonilamino, aminocarbonilalquil C1-6 aminoalquil C1-6 sulfonilamino, heterocicloalquiloxi C2-9 carbonilaminoalquil C1-6 sulfonilamino, heteroariloxi C2-9carbonilaminoalquil C1-6 sulfonilamino, cianoguanidino, alquil C1-6 cianoguanidino, (alquil C1-6)2 cianoguanidino, heterocicloalquil (C2-9) cianoguanidino, heteroaril C2-9 cianoguanidino, heterocicloalquil C2-9 alquil C1-6 cianoguanidino, heteroarilC2-9 alquil C1-6 cianoguanidino, aminoalquil C1-6 cianoguanidino, alquil C1-6 aminoalquil C1-6 cianoguanidino, (alquil C1-6)2 aminoalquil C1-6 cianoguanidino, aminocarbonilalquil C1-6 cianoguanidino, alquil C1-6 aminocarbonilalquil C1-6cianoguanidino, (alquil C1-6)2 aminocarbonilalquil C1-6 cianoguanidino, aminocarbonilalquil C1-6 amino, alquil C1-6 sulfonilaminoalquil C1-6 amino, alcoxi C1-6 carbonilaminoalquil C1-6 amino, aminosulfonilalquil C1-6 amino, heteroaril C2-9 alquilC1-6 amino, acetilaminoalquil C1-6 amino, (acetil)(alquil C1-6) aminoalquil C1-6 amino, alcoxi C1-6 carbonilalquil C1-6 aminoalquilo C1-6, cianoalquil C1-6 aminoalquilo, aminocarbonilalquil C1-6 aminoalquilo C1-6, acetilaminoalquil C1-6 aminoalquiloC1-6, (acetil)(alquil C1-6) aminoalquil C1-6 aminoalquilo C1-6, alcoxi C1-6 carbonilaminoalquil C1-6 aminoalquilo C1-6, heterocicloalquiloxi C2-9 carbonilaminoalquil C1-6 aminoalquilo C1-6, heteroariloxi C2-9 carbonilaminoalquil C1-6 aminoalquiloC1-6, cianoguanidinoalquil C1-6 aminoalquilo C1-6, alquil C1-6 cianoguanidinoalquil C1-6 aminoalquilo C1-6, (alquil C1-6)2 cianoguanidinoalquil C1-6 aminoalquilo C1-6, alquil C1-6 sulfonilaminoalquil C1-6 aminoalquilo C1-6, ureidoalquil C1-6aminoalquilo C1-6, alquil C1-6 ureidoalquil C1-6 aminoalquilo C1-6, (alquil C1-6)2 ureidoalquil C1-6 aminoalquilo C1-6, aminocarboniloxialquil C1-6 aminoalquilo C1-6, aminocarbonilalquil C1-6 carbonilaminoalquilo C1-6, alquil C1-6aminocarbonilalquil C1-6 carbonilaminoalquilo C1-6, (alquil C1-6)2 aminocarbonilalquil C1-6 carbonilaminoalquilo C1-6, aminosulfonilalquil C1-6 carbonilaminoalquilo C1-6, heterocicloalquiloxi C2-9 carbonilaminoalquilo C1-6, heterocicloalquil C2-9carbonilaminoalquil C1-6 carbonilaminoalquilo C1-6, cianoguanidinoalquil C1-6 carbonilaminoalquilo C1-6, cianoalquil C1-6 carbonilaminoalquilo C1-6, aminoalquil C1-6 aminocarbonilaminoalquilo C1-6, alquil C1-6 aminoalquil C1-6aminocarbonilaminoalquilo C1-6, (alquil C1-6)2 aminoalquil C1-6 aminocarbonilaminoalquilo C1-6, hidroxialquil C1-6 aminocarbonilaminoalquilo C1-6, aminocarbonilalquil C1-6 aminocarbonilaminoalquilo C1-6, alquil C1-6 carbonilaminoalquil C1-6aminocarbonilaminoalquilo C1-6, alquil C1-6 sulfonilaminoalquil C1-6 aminocarbonilaminoalquilo C1-6, alcoxi C1-6 carbonilaminoalquil C1-6 aminocarbonilaminoalquilo C1-6, heterocicloalquiloxi C2-9 carbonilaminoalquil C1-6 aminocarbonilaminoalquiloC1-6, heteroariloxi C2-9 carbonilaminoalquil C1-6 aminocarbonilaminoalquilo C1-6, heterocicloalquil c2-9 alquil C1-6 aminocarbonilaminoalquilo c1-6, heteroaril C2-9 alquil C1-6 aminocarbonilaminoalquilo C1-6, ureidoalquil C1-6 ureidoalquilo C1-6,alquil C1-6 ureidoalquil C1-6 ureidoalquilo C1-6, (alquil C1-6)2 ureidoalquil C1-6 ureidoalquilo C1-6, cianoguanidinoalquil C1-6 ureidoalquilo C1-6, haloalquil C1-6 sulfonilaminoalquilo C1-6, aminoalquil C1-6 sulfonilaminoalquilo C1-6, alquil C1-6aminoalquil C1-6 sulfonilaminoalquilo C1-6, (alquil C1-6)2 aminoalquil C1-6 sulfonilaminoalquilo C1-6, acetilaminoalquil C1-6 sulfonilaminoalquilo C1-6, (acetil)(alquil C1-6) aminoalquil C1-6 sulfonilaminoalquilo C1-6, ureidoalquil C1-6sulfonilaminoalquilo C1-6, alquil C1-6 ureidoalquil C1-6 sulfonilaminoalquilo C1-6, 8alquil C1-6)2 ureidoalquil C1-6 sulfonilaminoalquilo C1-6, alquil C1-6 sulfonilaminoalquil C1-6 sulfonilaminoalquilo C1-6, cianoguanidinoalquil C1-6sulfonilaminoalquilo C1-6, alquil C1-6 (cianoguanidino) alquil C1-6 sulfonilaminoalquilo C1-6, (alquil C1-6)2 (cianoguanidino)alquil C1-6 sulfonilaminoalquilo C1-6, aminocarbonilalquil C1-6 sulfonilaminoalquilo C1-6, alcoxi C1-6 carbonilaminoalquilC1-6 sulfonilaminoalquilo C1-6, heterocicloalquiloxi C2-9 carbonilaminoalquil C1-6 sulfonilaminoalquilo C1-6, heteroariloxi C2-9 carbonilaminoalquil C1-6 sulfonilaminoalquilo C1-6, aminosulfonilaminoalquilo C1-6, alquil C1-6aminosulfonilaminoalquilo C1-6, (alquil C1-6)2 aminosulfonilaminoalquilo C1-6, cianoguanidinoalquilo C1-6, alquil C1-6 (cianoguanidino)alquilo C1-6, (alquil C1-6)2 (cianoguanidino)alquilo C1-6, heterocicloalquil C2-9 (cianoguanidino) alquilo C1-6,heterocicloalquil C2-9 alquil C1-6 (cianoguanidino) alquilo C1-6, heterocicloalquil C2-9 (cianoguanidino) amino, heteroaril C2-9 (cianoguanidino) alquilo C1-6, heteroaril C2-9 alquil C1-6 (cianoguanidino) alquilo C1-6, aminoalquil C1-6(cianoguanidino) alquilo C1-6, alquil C1-6 aminoalquil C1-6 (cianoguanidino) alquilo C1-6, (alquil C1-6)2 aminoalquil C1-6 (cianoguanidino) alquilo C1-6, aminocarbonilalquil C1-6 (cianoguanidino) alquilo C1-6, alquil C1-6 aminocarbonilalquil C1-6(cianoguanidino) alquilo C1-6, (alquil C1-6)2 ?aminocarbonilalquil C1-6 (cianoguanidino) alquilo C1-6, aminosulfonilo, alquil C1-6 aminosulfonilo, (alquil C1-6)2 aminosulfonilo, heterocicloalquil C2-9 sulfonilo, aminoalquil C1-6 aminosulfonilo,alquil C1-6 aminoalquil C1-6 aminosulfonilo, (alquil C1-6)2 aminoalquil C1-6 aminosulfonilo, heteroaril C2-9 aminosulfonilo, hidroxialquil C1-6 aminosulfonilo, alcoxi C1-6 alquil C1-6 aminosulfonilo, ureido alquil C1-6 aminosulfonilo, alquil C1-6ureidoalquil C1-6 aminosulfonilo, (alquil C1-6)2 ureidoalquil C1-6 aminosulfonilo, alquil C1-6 sulfonilaminoalquil C1-6 aminosulfonilo, alcoxi C1-6 carbonilaminoalquil C1-6 aminosulfonilo, heterocicloalquiloxi C2-9 carbonilaminoalquil C1-6aminosulfonilo, heteroariloxi C2-9 carbonilaminoalquil C1-6 aminosulfonilo, aminocarbonilalquilo C1-6 aminosulfonilo, cianoguanidinoalquil C1-6 aminosulfonilo, heteroaril C2-9 alquil C1-6 aminosulfonilo, heterocicloalquil C2-9 aminosulfonilo; R6 esde 1 a 3 grupos seleccionados independientemente entre hidrógeno, hidroxi, hidroxisulfonilo, halo, alquilo C1-6, mercapto, mercaptoalquilo C1-6, alquiltio C1-6, alquil C1-6 sulfinilo, alquil C1-6 sulfonilo, aril C6-10 sulfonilo, alquil C1-6tioalquilo C1-6, alquil C1-6 sulfinilalquilo C1-6, alquil C1-6 sulfonilalquilo C1-6, alcoxi C1-6, hidroxialcoxi C1-6, ariloxi C6-10, haloalquilo C1-6, trifluoroalquilo C1-6, formilo, formilalquilo C1-6, nitro, nitroso, ciano, aril C6-10 alcoxi C1-6,haloalcoxi C1-6, trifluoroalcoxi C1-6, aminoalcoxi C1-6, cicloalquilo C3-10, cicloalquil C3-10 alquilo C1-6, hidroxicicloalquil C3-10 alquilo C1-6, cicloalquil C3-10 amino, cicloalquil C3-10 aminoalquilo C1-6, cianoalquilo C1-6, alquenilo C2-6,alquinilo C2-6, arilo C6-10, aril C6-10 alquilo C1-6, aril C6-10 alquenilo C2-6, hidroxialquilo C1-6, (hidroxi) aril C6-10 alquilo C1-6, (alquil C1-6 amino) aril C6-10 alquilo C1-6, hidroxialquil C1-6 tioalquilo C1-6, hidroxialquenilo C2-6,hidroxialquinilo C2-6, alcoxi C1-6 alquilo C1-6, alcoxi C1-6 aril C6-10 alquilo C1-6, ariloxialquilo C1-6, aril C6-10 alcoxi C1-6 alquilo C1-6, amino, alquil C1-6 amino, (alquil C1-6)2 amino, aril C6-10 amino, aril C6-10 alquil C1-6 amino,aminoalquil C1-6 amino, heterocicloalquil C2-9 amino, heteroaril C2-9 amino, cicloalquil C3-10 (alquil C1-6) amino, alquil C1-6 carbonilamino, alcoxi C1-6 carbonilamino, alquenil C2-6 carbonilamino, cicloalquil C3-10 carbonilamino, aril C6-10carbonilamino, heterocicloalquil C2-9 carbonilamino, haloalquil C1-6 carbonilamino, alcoxi C1-6 alquil C1-6 carbonilamino, alcoxi C1-6 carbonilalquil C1-6 carbonilamino, (alquil C1-6 carbonil)(alquil C1-6) amino, (alcoxi C1-6 carbonil)(alquilC1-6)amino, alquil C1-6 sulfonilamino, aminoalquilo C1-6, alquil C1-6 aminoalquilo C1-6, (alquil C1-6)2 aminoalquilo C1-6, hidroxialquil C1-6 aminoalquilo C1-6, aril C6-10 aminoalquilo C1-6, aril C6-10 alquil C1-6 aminoalquilo C1-6, alquil C1-6carbonilaminoalquilo C1-6, aril C6-10 carbonilaminoalquilo C1-6, (alquil C1-6 carbonil) alquil C1-6 aminoalquilo C1-6, cicloalquil C3-10 (alquil C1-6) aminoalquilo C1-6, alcoxi C1-6 carbonilaminoalquilo C1-6, alcoxi C1-6 carbonilalquil C1-6carbonilaminoalquilo C1-6, (alcoxi C1-6 carbonil) (alquil C1-6) aminoalquilo C1-6, alquil C1-6 sulfonilaminoalquilo C1-6, (alquil C1-6 sulfonil) (alquil C1-6) aminoalquilo C1-6, aril C6-10 sulfonilaminoalquilo C1-6, (aril C6-10 sulfonil) (alquilC1-6 aminoalquilo C1-6, heterocicloalquil C2-9 aminoalquilo C1-6, heteroaril C2-9 aminoalquilo C1-6, alcoxi C1-6 carbonilo, aril C6-10 alcoxi C1-6 carbonilo, alquil C1-6 carbonilo, aril C6-10 carbonilo, aril C6-10 alquil C1-6 carbonilo,hidroxialcoxi C1-6 carbonilo, alcoxi C1-6 carbonilalquilo C1-6, aril C6-10 alcoxi C1-6 carbonilalquilo C1-6, alcoxi C1-6 alquil C1-6 carboniloxialquilo C1-6, (alquil C1-6)2 aminocarboniloxialquilo C1-6, alquil C1-6 carbonilalquilo C6-10, aril C6-10carbonilalquilo C1-6, aril C6-10 alquil C1-6 carbonilalquilo C1-6, aminocarbonilo, alquil C1-6 aminocarbonilo, (alquil C1-6)2 aminocarbonilo, aril C6-10 aminocarbonilo, aril C6-10 alquil C1-6 aminocarbonilo, (aminocarbonilalquil C1-6 aminocarbonilo,alquil C1-6 aminocarbonilalquil C1-6 aminocarbonilo, alcoxi C1-6 carbonilalquil C1-6 aminocarbonilo, (aminoalquil C1-6) aminocarbonilo, (hidroxialquil C1-6) aminocarbonilo, aminocarbonilalquilo C1-6, alquil C1-6 aminocarbonilalquilo C1-6, (alquilC1-6)2 aminocarbonilalquilo C1-6, aril C6-10 aminocarbonilalquilo C1-6, aril C6-10 alquil C1-6 aminocarbonilalquilo C1-6, amidino, hidroxiamidino, guanidino, ureido, alquil C1-6 ureido, aril C6-10 ureido, (aril C6-10)2 ureido, aril C6-10 alquil C1-6ureido, haloalquil C1-6 ureido, (alquil C1-6) (aril C6-10) ureido, (alquil C1-6)2 ureido, haloalquil C1-6 carbonilureido, ureidoalquilo C1-6, alquil C1-6 ureidoalquilo C1-6, (alquil C1-6)2 ureidoalquilo C1-6, aril C6-10 ureidoalquilo C1-6, (arilC6-10)2 ureidoalquilo C1-6, aril C6-10 alquil C1-6 ureidoalquilo C1-6, haloalquil C1-6 ureidoalquilo C1-6, (haloalquil C1-6)(alquil C1-6) ureidoalquilo C1-6, (alcoxi C1-6 carbonilalquil C1-6) ureidoalquilo C1-6, glicinamido, alquil C1-6 glicinamido,aminocarbonilglicinamido, alcoxi C1-6 alquil C1-6 carbonilglicinamido, (aminocarbonil) (alquil C1-6) glicinamido, (alcoxi C1-6 carbonilalquil C6-10 carbonil (alquil C1-6) glicinamido, (alcoxi C1-6 carbonilaminoalquil C1-6 carbonil) glicinamido, arilC6-10 carbonilglicinamido, (aril C6-10 carbonil)(alquil C1-6) glicinamido, (aril C6-10 alquil C1-6 aminocarbonil) glicinamido, aril C6-10 alquil C1-6 aminocarbonil)(alquil C1-6) glicinamido, aril C6-10 aminocarbonil) (alquil C1-6) glicinamido,glicinamidoalquilo C1-6, alaninamido, alquil C1-6 alaninamido, alaninamidoalquilo C1-6, heteroarilo C2-9, heterocicloalquilo C2-9, heteroaril C2-9 alquilo C1-6 y heterocicloalquil C2-9 alquilo C1-6; R7 es de 1 a 3 grupos seleccionadosindependientemente entre hidrógeno, hidroxi, halo, alquilo C1-6, alquil C1-6 sulfonilo, aril C6-10 sulfonilo, alcoxi C1-6, hidroxialcoxi C1-6, haloalquilo C1-6, formilo, nitro, ciano, haloalcoxi C1-6, alquenilo C2-6, alquinilo C2-6, arilo C6-10,aril C6-10 alquilo C1-6, amino, alquil C1-6 amino, (alquil C1-6)2 amino, aril C6-10 amino, aril C6-10 alquil C1-6 amino, alquil C1-6 carbonilamino, alcoxi C1-6 carbonilamino, alquenil C2-6 carbonilamino, cicloalquilcarbonilamino, aril C6-10carbonilamino, haloalquil C1-6 carbonilamino, alcoxi C1-6 alquil C1-6 carbonilamino, alcoxi C1-6 carbonilalquil C1-6 carbonilamino, (alquil C1-6 carbonil) (alquil C1-6) amino, (alcoxi C1-6 carbonil)(alquil C1-6) amino, alquil C1-6 sulfonilamino,aminoalquilo C1-6, alquil C1-6 aminoalquilo C1-6, (alquil C1-6)2 aminoalquilo C1-6, alquil C1-6 carbonilaminoalquilo C1-6, aril C6-10 carbonilaminoalquilo C1-6, (alquil C1-6 carbonil) (alquil C-6) aminoalquilo C1-6, alcoxi C1-6 carbonilaminoalquiloC1-6, alcoxi C1-6 carbonilo, aril C6-10 alcoxi C1-6 carbonilo, alquil C1-6 carbonilo, aril C6-10 carbonilo, aril C6-10 alquil C1-6 carbonilo, aminocarbonilo, alquil C1-6 aminocarbonilo, (alquil C1-6)2 aminocarbonilo, aril C6-10 aminocarbonilo,aminocarbonilalquilo C1-6, alquil C1-6 aminocarbonilalquilo C1-6, (alquil C1-6)2 aminocarbonilalquilo C1-6, aril C6-10 aminocarbonilalquilo C1-6, guanidino, ureido, alquil C1-6 ureido, ureidoalquilo C1-6, alquil C1-6 ureidoalquilo C1-6 yglicinamido; cada uno de R9 y R10 se selecciona independientemente entre el grupo compuesto por hidrógeno, alquilo C1-6, arilo C6-10, aril C6-10 alquilo C1-6, alquil C1-6 carbonilo, alquil C1-6 carbonilalquilo C1-6, aril C6-10 alquil C1-6 carbonilo,aril C6-10 alquil C1-6 carbonilalquilo C1-6, aminocarbonilo, alquil C1-6 aminocarbonilo, (alquil C1-6)2 aminocarbonilo y alcoxi C1-6 carbonilo; y cada uno de R11 y R12 se selecciona independientemente entre el grupo compuesto por hidrógeno, alquiloC1-6, arilo C6-10 aril C6-10 alquilo C1-6, hidroxi, alcoxi C1-6, hidroxialquilo C1-6, alcoxi C1-6 alquilo C1-6, amino, alquil C1-6 amino, (alquil C1-6)2 amino, alquil C1-6 carbonilamino, cicloalquil C3-8 carbonilamino, cicloalquil C3-8 alquil C1-6carbonilamino, alcoxi C1-6 carbonilamino, alquil C1-6 sulfonilamino, aril C6-10 carbonilamino, alcoxi C1-6 carbonilalquil C1-6 carbonilamino, aril C6-10 alquil C1-6 carbonilamino, (aril C6-10 alquil C1-6 carbonil)(alquil C1-6) amino, alquil C1-6carbonilaminoalquilo C1-6, cicloalquil C3-8 carbonilaminoalquilo C1-6, alcoxi C1-6 carbonilaminoalquilo C1-6, heterocicloalquil C2-9 carbonilaminoalquilo C1-6, aril C6-10 alquil C1-6 carbonilaminoalquilo C1-6, heteroaril C2-9 carbonilaminoalquiloC1-6, aril C6-10 sulfonilamino, alquil C1-6 sulfonilaminoalquilo C1-6, aminocarbonilamino, alquil C1-6 aminocarbonilamino, haloalquil C1-6 aminocarbonilamino, (alquil C1-6)2 aminocarbonilamino, aminocarbonilaminoalquilo C1-6, alquil C1-6aminocarbonilaminoalquilo C1-6, (alquil C1-6)2 aminocarbonilaminoalquilo C1-6, haloalquil C1-6 aminocarbonilaminoalquilo C1-6, aminoalquilo C1-6, alquil C1-6 aminoalquilo C1-6, (alquil C1-6)2 aminoalquilo C1-6, carboxialquilo C1-6, alcoxi C1-6carbonilalquilo C1-6, aminocarbonilalquilo C1-6 y alquil C1-6 aminocarbonilalquilo C1-6.